Dr. Harris: Actually, I do have a question for Dr. Cooper. When Amy first told you about her approach to synaptic tracing, did you think it was gonna revolutionize the field?
Sheldon: Really? That's your question? What are you, Entertainment Tonight?

Amy: Did the electricity go out?
Sheldon: I don't know what you mean by "electricity," ma'am. I am just a farmer boy living in a little house on the prairie.

Sheldon: Would you like some advice?
Leonard: Sure, why not?
Sheldon: Then this is the perfect time to launch a blog with an interactive comments section.
Leonard: Gee, thanks a lot.

Amy: Is that butter?
Sheldon: Yes. But don't blow it all on one biscuit. Took me nine hours to make that. I think I got churner's elbow.

Howard: I've been at this lab for three years, you've never came by to say hello.
Sheldon: Well, up until now I've had better things to do. So, what are we making today?
Howard: A small payload support structure for a European science experimental package that's going up on the next space shuttle.
Sheldon: Really, how does it work?
Howard: When this is done, it will be attached to the payload bay, and the sensor apparatus will rest on it.
Sheldon: Uh, huh. So it's a shelf?
Howard: No, you don't understand, during acceleration it needs to stay perfectly level and provide ... yeah, okay, it's a shelf.

Sheldon: As much as I'd love to meet Euclid, inventor of the geometric proof, he probably wore sandals and I can not look at toes during dinner.

Sheldon: You know, surprisingly, the letter from your father wasn't the most interesting thing I read in the closet. Bernadette's diary has some saucy passages.
Bernadette: Sheldon, don't you dare.
Sheldon: There's nothing to worry about. Your secret's safe with me.
Bernadette: That's more like it.
Sheldon: Although copyright law would allow me to quote snippets in the context of a review.

Sheldon: Howard, I've had my eye on this limited edition Swamp Thing, but now that I'm about to buy it, I'm having second thoughts. What do you think?
Howard: I don't know, Sheldon, it's pretty expensive.
Sheldon: Yes, but what if it will make me happy, you know, waking up and seeing it every morning for the rest of my life?
Howard: Really, a walking clump of swamp grass?
Sheldon: Yeah, well, Bernadette's no prize either!

Amy: The last time we were in this room, we were getting married.
Sheldon: I remember. It's a lot less impressive without Mark Hamill in it.
Amy: That's what you said about our honeymoon.
Sheldon: And I stand by it.

Sheldon: Now to business. Eighteen years ago, I sent the FBI Crime Lab samples from a bag of excrement that had been lit on fire on my front porch for fingerprinting and DNA analysis. Why haven't I heard back yet?
Agent Page: Well, the FBI Crime Lab does have a lot on its plate.
Sheldon: That's of little comfort to a nation attempting to scrape burning faeces off its shoes.

Employment adviser: So, Mr. Cooper, you're looking for a job?
Sheldon: A menial job. Like yours.
Employment adviser: Why thank you for noticing. I'm Menial Employee of the Month.

Sheldon: This is how you're going to entertain your little cousin and his friends? By lying to them?
Howard: How is this lying?
Sheldon: A magic show is an inherently deceitful proposition. This is an ordinary top hat. You've chosen that card freely. I do not have a set of lock picks lodged in my keister.
Raj: Can't you just enjoy the wonder, Sheldon? Why must you peek behind the curtain? Or up the butt?
Sheldon: If we poison the critical thinking faculties of children by telling them that rabbits come out of hats, then we create adults who believe in astrology and homeopathy and that Ryan Reynolds was a better choice for Green Lantern than lovable rogue Nathan Fillion.

Sheldon: They can't just cancel a show like Alpha, you know. They have to help the viewers let go. Firefly did a movie to wrap things up. Buffy the Vampire Slayer continued on as a comic book. Heroes gradually lowered the quality season by season 'til we were grateful it ended.

Amy: Okay, what's the next test?
Sheldon: Loyalty. We need to choose someone who has our backs, someone who will keep our secrets even from each other.
Amy: Well, I don't have any secrets from you. Do you have secrets from me?
Sheldon: Yes. Oh, that has been weighing on me for years.

Sheldon: How are you feeling?
Amy: Ugh. My stomach aches, I got the chills, my mouth tastes weird, it hurts to swallow, and I've got a little double vision.
Sheldon: Yeah. I'm feeling better, too.