Amy: I've seen and talked to you more in the two days we've been broken up than in the last two months we were together.
Sheldon: Well, if you want to see less of me, maybe we should go out again.

Sheldon: Why are you up?
Leonard: How am I supposed to sleep? I've been married less than twenty-four hours and my wife isn't speaking to me.
Sheldon: Perhaps you can think of this in a more positive light. In one day, you've managed to do what it takes many couples decades to achieve.

Penny: You couldn't sleep either?
Leonard: Of course not.
Sheldon: Me neither. But I just had a tickle in my throat. Not profound marital problems.

Sheldon: The way I see it, there's a simple solution. Your lips had a dalliance with the lips of another woman. It seems only logical that to restore balance to the relationship, you should find another man and dally with him. And by dally, I mean some hardcore mouth-on-mouth action.

Leonard: I can't believe I'm spending my wedding night with you.
Sheldon: Really? I never imagined it any other way.

Sheldon: You would never make me kiss you, then say I love you, then break up with me.
Leonard: I wouldn't.
Sheldon: You know why? Because you're a man. The champagne of genders.
Leonard: I may be a man, but I think I'm the one that screwed up on this one.
Sheldon: And you admit it. Like a man. All your hear woman say is "I'll have a salad", "Where's my lip gloss?", "I think this element should be called radium."
That last one was Madame Curie.
Leonard: I figured that out.
Sheldon: You know what? She was sort of an honorary man. She had a penis made of science.

Penny: Well, I told her to be true to herself and do what makes her happy.
Sheldon: Do what makes her happy? She plays the harp and her car is paid for. How much happier can she be?

Sheldon: Would you mind opening the door and then angrily slamming it behind me?
Penny: Sure.
Sheldon: Thank you.
And slam it hard, because I am pretty steamed.

Sheldon: You know, this might sound far-fetched, but I'm on the market now. If I dated Mandy, that would teach both Leonard and Amy a lesson.
Penny: That's ridiculous.
Sheldon: Oh, you're right. I could never be with a woman whose self-esteem is so low she could be with Leonard.
Penny: I'm with Leonard.
Sheldon: Yeah, I know. Forever.

Sheldon: Oh, you don't need to worry about her. She's brilliant and attractive. She can do way better than Leonard.

Sheldon: It turns out being sweet isn't enough to keep a girl these days. I blame Madonna.

Penny: What's this?
Sheldon: Leonard told me what happened, so I took it upon myself to make you a hot beverage.
Penny: Oh, that's so sweet of you.
Sheldon: I know.

Sheldon: Wow. Marriage must agree with you. You are just glowing.
Leonard: I'm not glowing. I'm upset.
Sheldon: Well, whatever it is, it agrees with you.

Sheldon: Knock, knock, knock, Penny. Knock, knock, knock, Penny. Knock, knock, knock, Penny.

Sheldon: Hello, mother.
Mary Cooper: Shelly. How's my baby doing?
Sheldon: I just wanted to let you know that you can remove Amy from your nightly prayers. Unless you're open to praying for a bee hive to fall on her head.