Sheldon: Settle down there, fake Wolowitz. No one likes a kiss-up.

Sheldon: Penny, please don't hurt my friend.

Sheldon: If you're going to replace Wolowitz, I need to know a little bit more about you.
Stuart: All right.
Sheldon: Wolowitz went to MIT. What's your educational background?
Stuart: I went to art school.
Sheldon: Equally ridiculous. Let's go.

Sheldon: Leonard, the transformers teach us that things are not always what they appear to be. You know, like, a semi truck might be an alien robot, or someone in a romantic relationship might feel differently than they appear to.

Howard: You're out of your mind, Sheldon.
Sheldon: That's a negative. My mother had me tested. Over.

Leonard: Sheldon, you are not in charge.
Sheldon: That's mighty sassy for a man with a roommate performance review around the corner.

Sheldon: How can she not be sure how she feels? You know, when I have a feeling, I know it. Trains? Love them. Swordfish. I love them, too. They're fish with a sword for a nose.

Sheldon: FYI, secret keeping? Hate it. Hand-holding? Not a fan. Hammerhead shark? I love that thing. Yeah, it's another fish with a tool on its head.

Leonard: Okay, I think I understand.
Sheldon: You do?
Leonard: The guy who seems like an emotionless robot is you, but your relationship with Amy is causing you to transform into a red-blooded man with sexual desires.
Sheldon: That is literally the stupidest thing I've ever heard.

Sheldon: Leonard, maybe you'd like to go with them to meet girls.
Leonard: Why would I be interested? I have Penny.
Sheldon: Yeah, for now. But that woman has a death wish, Leonard. She talks to strangers, she pets unfamiliar dogs, and it is ridiculously easy to break into her apartment. If I were you, I'd get a back-up.

Sheldon: Okay, my turn. Let me talk to him.
Leonard: Go ahead.
Sheldon: 2311 North Los Robles Avenue, Pasadena, California to International Space Station. Can you read me? Over. (Makes static noise)
Howard: Yes, I read you, Sheldon.
Sheldon: Copy that. Over. (Static)
Leonard: What are you doing?
Sheldon: I am talking to a man in space. If you don't have the (static) then he might as well be at the Coffee Bean over on Lake Street.
Howard: You're out of your mind, Sheldon!
Sheldon: That's a negative. My mother had me tested. Over.

Raj: What's the big deal? You guys are bringing your girlfriends. I didn't want to sit by myself.
Sheldon: The big deal is I was expecting us to be an intimate group of five. Now, we're going to be a faceless mass of six.

Leonard: It'll be fine. Just, uh, pretend he's Wolowitz.
Sheldon: Hmm. Do you like Raisinets?
Stuart: I can take them or leave them.
Sheldon: At the movies, Wolowitz always eats Raisinets.
Stuart: Would you feel more comfortable if I ate Raisinets?
Sheldon: Well, it's hardly my business what you eat. As long as it doesn't crunch during the film and it's Raisinets.

Amy: Penny said she's not sure she wants to be Leonard's girlfriend anymore.
Sheldon: Wrong. She just took a sip from his Diet Dr. Pepper.
Amy: So?
Sheldon: So, if she wants to end her pair-bond with Leonard, why on earth would she guzzle a witches' brew of his soda and spit?

Stuart: Raisinet?
Sheldon: Shh, we're trying to watch the movie. (To Amy) This is not working out with him.