Sheldon: My aunt and uncle were married 63 years. Towards the end, it was like watching cheese melt.

Sheldon: What if she ends up with a toddler who doesn't know if he should use an integral or a differential to solve for the area under a curve?
Leonard: I'm sure she'll still love him.
Sheldon: I wouldn't.

Raj: I don't know if I wanna play any more.
Sheldon: Because you don't have a girlfriend? Well, good lord, if that becomes a reason to not play dungeons and dragons, this game is in serious trouble.

Leonard: I just assumed. Who sells a full-sized time machine for $800?
Sheldon: In a Venn diagram that would be an individual located within the intersection of the sets 'no longer want my time machine' and 'need $800'.

Sheldon: Well then, as my meemaw would say, looks like we butchered a pig but nobody wanted bacon.

Sheldon: Thank you Kripke for depriving me of the opportunity to share my news with my friends.
Kripke: My pleasure.
Sheldon: My thank you was not sincere.
Kripke: Hmm, but my pleasure is.

Sheldon: Well if it isn't Wil Wheaton, the Jar Jar Binks of the Star Trek Universe.

Penny: Ugh, I cannot believe Christy let Howard into my apartment.
Sheldon: And I cannot believe people pay for horoscopes. But on a more serious note, it's 8:13 and we're still not playing "Halo".

Sheldon: To amend the words of Toy Story, you have not got a friend in me.

Sheldon: Oh, Ubuntu. You're my favorite Linux-based operating system.

Sheldon: Biologists are mean.

Sheldon: And good evening to you, Siam Palace, this is Sheldon Cooper. Yeah, I'm going to be dining alone this evening, so I'll be reducing my usual order. I'd like to start with one quarter of the assorted appetizers plate and one half of the Golden Treasure for two - oh, for heaven's sake! In the mid-18th century, King Rama the Fourth of Siam divided a huge empire amongst the colonial powers of Europe in order to preserve his throne. Surely you, his cultural descendant, can handle pad thai and dumplings.

Sheldon: Where exactly does the half-sandwich come from? Are you giving me half of someone else's sandwich, or do I have to wait for someone in the restaurant to order the other half?

Sheldon: Clarify something for me. Isn't the point of a communal meal the exchange of ideas and opinions, an opportunity to consider important issues of the day?
Leonard: It is. You just kinda put a damper on things when you said, 'The next person I see talking with food in their mouth will be put to death'.

Sheldon: All right, we're going to be designing an experiment to look for the annihilation spectrum resulting from dark matter collisions in space.
Raj: Ooh, dark matter. We better bring a flashlight, ha, ha.
Sheldon stares at Raj.
Raj: I was making a joke.
Sheldon: I'm the boss. I make the jokes.
Raj: Sorry, go ahead and make your joke.
Sheldon: This is not the time for joking.