Sheldon: There's always a chance that alcohol and poor judgment on her part may lead to a wonderful evening.
Sheldon: I think that you [Leonard] have as much of a chance of having a sexual relationship with Penny as the Hubble telescope does of discovering at the center of every black hole is a little man with a flashlight searching for a circuit breaker.
Wolowitz: So, how’d it go with Leslie?
Leonard: Oh, we tried kissing, but the earth didn’t move… I mean any more than the 383 miles it was gonna move anyway!
Sheldon: You have about as much chance with her as the Hubble Telescope does of finding in the middle of each black hole a small man looking for the light switch.
Sheldon: I don't come over to your house changing things on your boards.
Leslie: That's because I don't have mistakes on my boards.
Sheldon: That's...That's...
Leslie: When you think up an adjective text me.
Sheldon: (to Leonard, who has decided to give up on Penny) Well, at least now you can retrieve the black box from the twisted, smoldering wreckage that was once your fantasy of dating her and analyze the data so you don't crash into Geek Mountain again.
Wolowitz: Love is not a sprint, it's a marathon, a relentless pursuit that only ends when she falls into your arms - or hits you with the pepper spray.
Leonard: Homo habilis discovering his opposable thumbs says what?