Stewart (comic book guy): Calling a tomato a vegetable is a little wrong, calling it a suspension bridge is very wrong.
Wolowitz: I am a horny engineer, I never joke about math or sex.
Howard [to Leonard]: Are you familiar with the Drake Equation?
Sheldon: The one that estimates the odds of making contact with extraterrestrials by calculating the product of an increasingly restrictive series of fractional values such as those stars with planets, and those planets likely to develop life? N equals R times FP times NE times FL times FI times FC times L?
[pause]
Howard: Yeah, that one.
Penny: Um, you know it's kinda early. Do you wanna maybe come in for some coffee or something?
Stuart: Oh gee, its a little late for coffee isn't it?
Penny: Aw, you think coffee means coffee. That is so sweet.