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Leslie: Oh, Leonard, you magnificent beast.

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3
From episode The Hamburger Postulate.

Mary Cooper: Honey, why did you get a loom?
Sheldon: Well, I was working with luminous fish and I thought... Hey. Loom.

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3
From episode The Luminous Fish Effect.

Penny: I think I caught the flu. *Throwing up*. Or the plague!

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3

Sheldon (to his mom): But, evolution is not opinion, it's a fact!
Sheldon's mom: And that is your opinion!
Sheldon (to Leonard, Howard and Raj): I forgive you, let's go home.

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4.3

Penny: Boy, you're really smart.
Leonard: Yeah, I'm a freaking genius.

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4

[Sheldon is refusing to buy a present for Leonard]
Howard: [to Penny] Try telling him it's a non optional social convention.
Penny: What?
Howard: Just do it!
Penny: [to Sheldon] It's a non optional social convention.
Sheldon: Oh! Fair enough.
[Penny surprised]
Howard: He came with a manual.

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4
From episode The Peanut Reaction.

Penny: Who's Adam West?
Sheldon: Who's Adam West!? Leonard, what do the two of you talk about after the coitus?

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4.7

Howard: I'll bet your Meemaw didn't just have sex to have your mother, I bet she had sex because she liked it.
Sheldon: Stop it!
Raj: Yeah! Meemaw did the nasty!
Sheldon: I said stop it!
Howard: We're getting to him.

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4.5

Wolowitz: Where's my dad, puppet?!

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4

Sheldon: So, just to clarify, when you say 3, do we stand up or do we pee?

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4.5