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Quote from Howard in the episode The Tangerine Factor

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Quote from Sheldon in the episode Pilot

Leonard: Our babies will be smart and beautiful.
Sheldon: Not to mention imaginary.

Quote from Mrs. Wolowitz in the episode The Pancake Batter Anomaly

Mrs. Wolowitz Howard, it's the phone.
Howard: I know it's the phone, Ma. I can hear the phone.
Mrs. Wolowitz Well who's calling at this ungodly hour?
Howard: I don't know.
Mrs. Wolowitz Well ask them why they're calling at this ungodly hour.
Howard: How can I ask them when I'm talking to you?

Quote from Raj in the episode The Dumpling Paradox

Leonard: Well, the only way we can play teams at this point is if we cut Raj in half.
Raj: Oh, sure, cut the foreigner in half. There's a billion more where he came from.

Quote from Howard in the episode The Bat Jar Conjecture

Wolowitz: That's more like we're a tall thin woman who wants to make a coat out of your Dalmatians.

Quote from Mary Cooper in the episode The Luminous Fish Effect

Mary: He gets his temper from his daddy.
Leonard: Ah!
Mary: He's got my eyes.
Leonard: I see!
Mary: All that science stuff, that comes from Jesus.

Quote from Mary Cooper in the episode The Luminous Fish Effect

Mary Cooper: I'm sorry, did I start that sentence with the words, "If it pleases your highness?"

Quote from Howard in the episode Pilot

Howard: Wait till you see this.
Raj: It's fantastic. Unbelievable!
Leonard: See what?
Howard: (Putting in DVD) It's a Stephen Hawking lecture from MIT in 1974.
Leonard: This isn't a good time.
Howard: (Imitating Stephen Hawking) It's before he became a creepy computer voice.

Quote from Howard in the episode The Peanut Reaction

Howard: Try telling him it's a non-optional social convention.
Penny: What?
Howard: Just do it!
Penny: It's a non-optional social convention.
Sheldon: Oh, fair enough.
Howard: He came with a manual.

Quote from Penny in the episode The Grasshopper Experiment

Leonard: I don't believe it. What's gotten into him?
Penny: Oh, maybe a couple of virgin Cuba Libres that turned out to be kinda slutty.
Leonard: You didn't.
Penny: Hey, you do your little experiments, I do mine.

Quote from Raj in the episode The Bat Jar Conjecture

Sheldon: Teams are traditionally named after fierce creatures thus intimidating one's opponent.
Raj: Then we could be the Bengal tigers.
Sheldon: Poor choice. You know, gram for gram no animal exceeds the relative fighting strength of the army ant.
Raj: Maybe so, but you can't incinerate a Bengal tiger with a magnifying glass.

Quote from Sheldon in the episode The Big Bran Hypothesis

Sheldon: Oh gravity, thou art a heartless bitch.

Quote from Sheldon in the episode Pilot

Sheldon: Do you want to hear an interesting thing about stairs?
Leonard: Not really!
Sheldon: If the height of a step is off by as little as two millimeters, most people will trip.
Leonard: I don't care. 2 millime--? That doesn't seem right.
Sheldon: It's true. I did a series of experiments when I was 12. My father broke his clavicle.
Leonard: Is that why they sent you to boarding school?
Sheldon: No. That was the result of my work with lasers.

Quote from Mary Cooper in the episode The Luminous Fish Effect

Mary Cooper: Dr. Gablehouser, are you busy?
Dr. Gablehouser: Well, actually.
Mary Cooper: Sheldon, he's just doodlin'. Get in here.

Quote from Howard in the episode The Pork Chop Indeterminacy

Rajesh: Missy. Do you enjoy pajamas?
Missy: I guess.
Rajesh: Yes, well, we Indians invented them. You're welcome.
Howard: Yeah, well my people invented circumcision. You're welcome.

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