Howard: All right, well, something's obviously bugging you. What is it?
Bernadette: I just can't believe you signed up for the space program without even talking to me.
Howard: Oh, I get it. You're worried about me. That is so sweet. You know, there's a saying we have at NASA. What makes the right stuff so right is that it always comes home.
Bernadette: Just stop talking, Howard.

Howard: This isn't the reaction I expected when I told you I was gonna be an astronaut.
Bernadette: What did you think was going to happen?
Howard: Honestly? Sex.
Bernadette: Howard!

Howard: Do you realize what a big deal this is? What an honor it is to be chosen to go into space?
Bernadette: Yeah, I get it. I just wish you included me in the decision. We're supposed to be partners. We're supposed to be a team.
Howard: I'm sorry. You're right. Okay, let's try this again. Bernadette, an opportunity has come up that impacts both of us, and I'd like to discuss it.
Bernadette: Okay.
Howard: I've been offered a chance to go up to the International Space Station for three weeks. What are your thoughts on that?
Bernadette: Well, first of all, thank you for including me in the decision-making process.
Howard: Hey, we're a team. So, what do you think?
Bernadette: No.
Howard: No?
Bernadette: No.

Leonard: Pretty cool about Howard, huh?
Sheldon: Dont talk to me as if nothing's happened between us. And yes, it sure is, buddy.
Leonard: For God's sake, will you stop with the Schrodinger stuff?
Sheldon: Would you prefer a simpler application of Heisenberg's uncertainty principle, in which I could either know where you are or whether I like you, but not both?
Leonard: You never stop talking, do you?

Raj: So, what's gonna happen next? Are you and Bernadette going to break up?
Howard: I don't know. If we're going to get back together, she's going to have to apologize and accept that I'm a grown man who can make his own decisions.
Raj: Then she's going to have to convince your mother to let you go into space.
Howard: Obviously.

Penny: Well, that, that's good. I'm glad you came to that. But before you do, let me just ask you a big picture question.
Bernadette: What?
Penny: Are you a hundred percent positive you love and want to marry Howard Wolowitz?
Bernadette: I do, with all my heart.
Penny: Got it. Just had to check.

Leonard: Hey, Sheldon?
Sheldon: Oh, good. You picked me, you picked me.
Leonard: No, I just got a text from Stuart. Brent Spiner is at the party.
Sheldon: Brent Spiner?
Leonard: Yes.
Sheldon: I don't care.
Leonard: Really? Brent Spiner, Mr. Data himself. You love him.
Sheldon: I did, but I think I've kind of outgrown Star Trek. You know, stock characters, ludicrous plots, beam me up. What a load of hooey.
Leonard: I'm going. Live long and prosper, Sheldon.
Sheldon: Yeah, even that. You look like a dork.

Howard: If you're gonna love me, you're gonna have to love the whole package, the tenderhearted poet and the crazy daredevil.
Bernadette: I know.
Howard: Well, don't say it if you're not gonna mean it, 'cause I'm not just gonna stop with the space station. Yeah, I want to go to the Moon, I want to go to Mars. I want to take a one-man sub to the lowest depths of the ocean.
Bernadette: Really? You got seasick on Pirates of the Caribbean.
Howard: Well, those big kids were rocking it.

Bernadette: I just did what I did because I love you so much, and the thought of losing you is more than I can handle.
Howard: Really?
Bernadette: You're my soul mate. This is where you kiss me.

Leonard: What are you doing here?
Sheldon: Fighting for our friendship. As peculiar and annoying as you can be, you're still my little buddy. I'm not going to let that end here tonight. Now put down that drink, let's meet Brent Spiner and go home.

Wil Wheaton: Hey, Sheldon, I'm so glad you made it. I found something I think you might like.
Sheldon: What I'd like is for him to have a more depressing home. This is quite lovely.

Wil Wheaton: This is for you.
Sheldon: An original mint-in-package Wesley Crusher action figure.
Wil Wheaton: I remembered your story about the time you went to a convention when you were a kid to get one signed, and I didn't show up.
Wil Wheaton: Look at what I wrote.
Sheldon: To Sheldon, sorry this took so long. Your friend, Wil Wheaton.
Wil Wheaton: It's my last one. I want you to have it.
Sheldon: Look, everyone. Wil Wheaton is my friend!

Leonard: Can we get autographed dolls?
Brent Spiner: Sure. Twenty bucks.
Leonard: Ten.
Brent Spiner: Eighteen.
Leonard: Twelve.
Brent Spiner: Sixteen.
Leonard: Two for thirty. And you come to my birthday party.
Brent Spiner: Done.

Sheldon: Does this mean you're not going to sing Soft Kitty?
Mary: No, I will always sing you Soft Kitty. [sings] Soft kitty, warm kitty, little ball of fur…
Leonard: [opens door] Mrs. Cooper, were we supposed to take that pie out of the oven?
Sheldon: Get out!
Mary: Well, that was rude.
Sheldon: Well, I know, but he means well. Sing.
Mary: [sings] Happy kitty, sleepy kitty…
Sheldon: What are you trying to pull, Mom? From the top.
Mary: [to God] This is what I'm talking about. [sings] Soft kitty, warm kitty, little ball of fur…

Sheldon: Come on out, merry pranksters. Take a bow!