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Quote from Sheldon in the episode The Jiminy Conjecture

Raj: I don't like bugs, okay. They freak me out.
Sheldon: Interesting. You're afraid of insects and women. Ladybugs must render you catatonic.

Quote from Howard in the episode The Anxiety Optimization

Howard: I invented a game. Want to play?
Leonard: Sure.
Howard: It's called Emily or Cinnamon. I give you actual quotes I've heard Raj say, and you guess if he was talking to his girlfriend or his dog.

Quote from Leonard in the episode The Graduation Transmission

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Quote from Mary Cooper in the episode The Mommy Observation

Sheldon: Well, this is confusing for me. But I don't want to stand in the way of your happiness. So, I will condemn you internally while maintaining an outward appearance of acceptance.
Mary: That is very Christian of you.

Quote from Sheldon in the episode The Lizard-Spock Expansion

Sheldon: Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and as it always has, rock crushes scissors.

Quote from Sheldon in the episode The Opening Night Excitation

Sheldon: (3 knocks) Penny! (3 knocks) Penny! (3 knocks) Penny!
Bernadette: What happens if I say come in?
Penny: Well, find out.
Bernadette: Come in!
Sheldon: (silence)
(3 knocks) Bernadette! (3 knocks) Bernadette! (3 knocks) Bernadette!
Penny: Come in!
Sheldon: Keep it up. I've got nowhere else to be.
Bernadette: Just come in.
Sheldon: For future reference, if I want to watch Mean Girls, I'll just stream it on Netflix.

Quote from Howard in the episode The Tangerine Factor

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Quote from Leonard in the episode The Graduation Transmission

Leonard: So, for the remainder of my speech, this is for the invisible kids. Maybe you never fit in. Or maybe you were the smallest kid in the school. Or the heaviest. Or the weirdest. Maybe you're graduating and you still haven't even had your first kiss. By the way, nineteen, and Geraldine Coco, wherever you are, thank you. Maybe you don't have any friends, and guess what, that's okay. While all the popular kids are off doing whatever - I don't know what they're doing because I was never there.

Quote from Bernadette in the episode The Intimacy Acceleration

Bernadette: You better find my husband's mother, 'cause one way or another we're walking out of this airport with a dead woman.

Quote from Stuart in the episode The Hofstadter Isotope

Stuart: Oh, Sheldon, I'm afraid you couldn't be more wrong.
Sheldon: More wrong? Wrong is an absolute state and not subject to gradation.
Stuart: Of course it is. It's a little wrong to say a tomato is a vegetable, it's very wrong to say it's a suspension bridge.

Quote from Amy in the episode The Proton Transmogrification

Amy: I guess it must have been back when I was in the Girl Sprouts.
Bernadette: Girl Sprouts?
Amy: My mom made it up as an alternative to the Girl Scouts. She didn't want me selling cookies on some street corner like a whore.

Quote from Mary Cooper in the episode The Rhinitis Revelation

Mary Cooper: It's all themed. There's Jonah and the Whale Watching. All-you-can-eat Last Supper Buffet. And my personal favorite, Gunning with God.

Quote from Sheldon in the episode The Gorilla Experiment

Sheldon: Why are you crying?
Penny: Because I'm stupid.
Sheldon: That's no reason to cry. One cries because one is sad. For example, I cry because others are stupid, and that makes me sad.

Quote from Amy in the episode The Opening Night Excitation

Amy: Okay, what is going on?
Penny: We just want you to be prepared for any surprises that could happen tomorrow.
Amy: What surprises?
Bernadette: We don't want to spoil anything, but you should know that Sheldon said he's ready to be physical.
Amy: You shut your damn mouth! You actually heard him say this?
Penny: Yes, he said he wants to do something to show you how much you mean to him.
Amy: I can't believe it. I don't know what to say.
Bernadette: Well, we're really happy for you and we know how much-
Amy: I do know what to say. Let's get me waxed!

Quote from Amy in the episode The Space Probe Disintegration

Penny: Do I really force you to do things you don't want to?
Amy: Yeah, but it's okay.
Penny: How is it okay?
Amy: I promised myself if I ever got friends I'd do whatever they said. Really, I'm lucky you found me before a cult did.

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