Bernadette: I dont know. Dead people's dresses?
Penny: Yeah, and cap sleeves?
Amy: I was hoping you wouldn't notice. Irene was always a slave to a good bargain when it came to clothes, and sadly as it turned out, space heaters.

Leonard: Hey, Amy, what brings you to our neck of the woods?
Amy: Your neurology department loaned me a culture of prions for my research on bovine spongiform encephalopathy.
Sheldon: She popped by to borrow a cup of mad cow disease.
Amy: It's hard to make degenerative brain maladies hilarious, and yet somehow you do it.

Amy: Sheldon, is it possible that your foul mood -- or, to use the clinical term, bitchiness -- is because your mother isn't making you a priority?
Sheldon: No. Or, to use the clinical term: "nuh-uh."

Amy: Now Sheldon, I know you're a left handed monkey wrench but you seriously have a mortal enemy
Sheldon: Yes, in fact I have 61. Would you like to see the list?

Penny: Wait, what is going on?
Sheldon: In case you have forgotten, Schrodinger's cat is a thought experiment.
Penny: No, no, no, no, I didn't forget. Um, there's this cat in a box and until you open it, it's either dead or alive or both. Although, back in Nebraska, our cat got stuck in my brother's camp trunk, and we did not need to open it to know there was all kinds of dead cat in there.
Amy: Homespun stories, knowledge of physics and a bosom that defies it. You're the whole package, aren't you?

Amy: It's not for us to judge. We're just here to provide comfort and support while you come to grips with what a despicable thing you've done.

Amy: The only person who signed my yearbook was my mother. "Dear Amy, self respect and a hymen are far better than friends and fun. Love, mom."

Amy: I have a sorta kinda boyfriend at home playing with a model train, but you don't hear me bitching about it.

Leonard: Aren't you going with Sheldon?
Amy: No, I have no interest in model trains, stores that sell them, nor their heartbreaking clientele.

Leonard: Well, I have some work to do, so-
Amy: I can't imagine that would disturb me. Carry on.
Leonard: Okay. Wouldn't you be more comfortable at home?
Amy: Not really, no.
Leonard: All righty then. Guess I'll just get started.
Amy: Leonard, please. I don't need the running commentary.

Amy: Should I go? I have been told sometimes I overstay my welcome.
Leonard: What? Who told you that?
Amy: Well, most recently my gynaecologist.

Penny: You're a brain scientist. Can you explain to me why a brilliant man likes playing with toy trains?
Amy: Not without cutting his head open, no.

Leonard: I just can't figure out what happened. I put my left leg in, I took my left leg out, I put my left leg in, and something just snapped.
Amy: The hokey pokey is a young man's game.

Amy: How was your shower?
Leonard: It was good, good. Just out of curiosity, what time do you usually go to bed?
Amy: Oh, I'm up all night. I'm like a possum.

Penny: You're a brain scientist. Can you explain to me why a brilliant man likes playing with toy trains?
Amy: Not without cutting his head open, no.