Howard: [Chuckles] Look at that. There's finally a woman in your life you can talk to.

Wolowitz: I mean, even Donkey Kong had Donkey Kong Jr. so he could teach someone how to kidnap princesses and throw barrels at Italian plumbers.

Wolowitz: My mother can be a pretty good shoulder to cry on. If the smell of Ben-Gay doesn't burn your eyes.

Howard: But don't you think it will be different when the child is ours?
Bernadette: Right, when it's our kid that has ruined my body, and kept me up all night, and I've got no career and no future, and nothing to be happy about for the next twenty years. Sure, that'll be completely different.
Howard: Well, yeah.

Howard: Completely empty box. If you'd like to examine it?
Leonard: Mm-hmm. Yep. I see nothing in this box but a wasted childhood.
Howard: Little snarky there, cello lessons.

Bernadette: Oh, you have a lot of magic stuff.
Howard: Yeah. I started when I was a teenager. I thought I could show a girl a few tricks and invite her up to my bedroom to see the rest of the act.
Bernadette: Did it work?
Howard: Ah, let's just say the only wand that ever saw any action was this one.

Raj: What's your mom going to say if you call off the wedding?
Howard: Huh, it'll kill her. On the other hand, if I don't give her grandchildren, that'll kill her, too. So, either way, on the Mom front, I'm golden.

Jimmy Speckerman: Yeah, we were practically a comedy team.
Wolowitz: Yeah, like the Black Death and Europe.

Howard: Hey, we're here to support you, buddy.
Leonard: No, you're not. You're here to see if I get my underwear pulled over my head.
Howard: You wore underwear? You fool.

Howard: It's amazing people keep coming to comic book stores instead of just downloading comics digitally.
Leonard: It's probably for the best. For a lot of these guys, the weekly trip here is the only chance their mom has to go down to the basement to change their sheets.
Howard: Oh, that reminds me, I get fresh sheets tonight. Yay!

Raj: Come on, Sheldon, Star Wars.
Howard: I'm pushing play. I mean it. If we don't start soon, George Lucas is going to change it again.

(Howard has just told Mary about his upcoming trip to the International Space Station.)
Mary Cooper: I bet your mom is really proud of you.
Howard: Nope. She says if I don't back out, she's gonna go on a hunger strike. It'd take years before she'd be in any kind of danger, but still.

Raj: None of our gods have abs like that.
Howard: Yep, that's the last Jew who did sit-ups. Look where it got him.

Howard: This isn't the reaction I expected when I told you I was gonna be an astronaut.
Bernadette: What did you think was going to happen?
Howard: Honestly? Sex.
Bernadette: Howard!

Raj: So, what's gonna happen next? Are you and Bernadette going to break up?
Howard: I don't know. If we're going to get back together, she's going to have to apologize and accept that I'm a grown man who can make his own decisions.
Raj: Then she's going to have to convince your mother to let you go into space.
Howard: Obviously.