Penny: is he quitting his job at the university?
Leonard: Oh no, he's going to telecommute. Everybody's really excited about it.

Leonard: What do you want?
Sheldon: It's not what I want, it's what evolution wants. Human beings are primates. Primates have evolved to live in groups, both for protection and support.
Leonard: But you don't like other people.
Sheldon: I do tonight. It's scary over there.
Leonard: It's getting scary here, too.

Penny: Look, Sheldon, sweetie, I know you're feeling insecure, but we've really got to go to sleep.
Sheldon: All right. I'll take the first watch and wake you at 0400.
Leonard: Great. Good night.
Penny: Wait, wait, what's 0400?
Leonard: 4 am.
Penny: That's, like, in 45 minutes.
Leonard: Just keep walking.

Leonard: I'm sorry, but facts are facts.
Penny: Right, and if you can't understand it, it's not a fact.
Leonard: No, if it's not a fact, it's not a fact.

Howard: Listen, before we leave, I should warn you, I'm a passionate man and I tend towards public displays of affection.
Leonard: What are you trying to tell me, Howard?
Howard: There might be some making out in the car or the restaurant, and I don't want Bernadette to feel uncomfortable, so it would help if you and Penny made out, too.
Leonard: Don't worry. We're planning to have sex right on the salad bar.

Bernadette: How's your work going, Penny? Any acting jobs?
Penny: Well, the last big thing I did was this production of Diary of Anne Frank above a bowling alley. But I think things might be turning around pretty soon.
Leonard: Great. How come?
Penny: Well, promise you won't make fun of me.
Leonard: Of course, I would never make fun of you.
Penny: Okay. Well, I went to this psychic who told me that if I cut my hair, I'm going to get a national commercial.
Leonard: (Laughing) Seriously? You're getting career advice from a psychic?
Howard: Good job not making fun of her.

Leonard: Hey. Cleaning out the old dryer lint, huh? Not only is it courteous, it's safety smart. Every year, 15,000 fires are caused by accidental dryer lint ignition. Now you're supposed to say, wow, what an interesting fact. Come here, you crazy, nerdy guy. I could never be mad at you.

Leonard: Merry Newtonmas everyone.

Leonard: I drove, mother. I'm driving now.
Beverly Hofstadter: Yes, dear. Mommy's proud.

Leonard: I'm fine. How are you?
Beverly Hofstadter: Menopausal.
Leonard: Now I'm less fine.

Leonard: (to Penny) It upsets Sheldon when you play with the Sheldon.

Bernadette: Come here, tushie face.
Leonard: Tushie face! That is going on twitter right now.

Leonard:What am I supposed to say? Sure, Penny, I'm cool with having your old boyfriend sleep in your apartment.
Leonard imitating Penny: Well, Leonard, it doesn't matter if you're cool or not, 'cause I'm penny and I'm pretty and I can do whatever the hell I want.

Leonard: So, by friend, do you mean friend friend, gay friend, or ex boyfriend who you're now platonic with but still might have a thing for your friend?
Penny: Well, he's definitely not gay.
Leonard: Oh, a definitely not gay musician sleeping on my girlfriend's couch. Yippee!

Penny: Oh and FYI, you never even heard of The Black Eyed Peas until you met me.
Leonard: I'd heard of them. Didn't know they were a band.