Mary Cooper: Well, I would have to say when he was thirteen and he tried to build a nuclear reaction in the tool shed.
Sheldon: Ooh, this is a good one.
Mary Cooper: Now, the first thing you need to know about Shelly is, ever since he was a little boy, he was always concerned with the well-being of others. And he didn't think it was fair for people to pay for electricity, so he was gonna power the entire town for free.
Sheldon: Tell her about the uranium. Tell her about the uranium!
Mary Cooper: Oh, well! Well, this is adorable. When he arranged to get some yellow-cake from Chad, I thought he was talking about twinkies from one of his friends.
Sheldon: Yeah. But I wasn't, because I didn't have any friends.
Mary Cooper: No. It turns out this little scallywag was trying to use my Visa card to buy uranium from an African warlord in the country of Chad.

Sheldon: Leonard's mom is a renowned psychiatrist and woman of science. Can you please keep the Bible babble to yourself while she's here?
Mary Cooper: Are you ashamed of me?
Sheldon: Of course not. I love you. I'm just embarrassed by the things you believe, do and say.
Mary Cooper: Well, I love you, too, my little bowl of lion chow.

Mary Cooper: I tried to read your paper, but it was very hard for me to understand.
Sheldon: Oh, it's quite straightforward, actually. It describes a new model of the universe that conceptualizes it as the surface of an n-dimensional superfluid.
Mary Cooper: Interesting. You can believe that, but God filling an ark with animals two-by-two is nonsense.
Sheldon: What did they feed the lions, Mother?
Mary Cooper: The floating bodies of drowned sinners, of course.

Mary Cooper: Oh, I so should have taken you to Houston.

Penny: Mrs Cooper, it smells so good.
Mary Cooper: You take notes, darling. The real way to get a man is with melted cheese and cream of mushroom soup. He'll die at fifty, but his love will be true.

Mary Cooper: I want to thank you for the blessing that is my little Shelly. I also want to thank you for the continued strength not to coldcock him with my bible.

Mary Cooper: Lord, Mary Cooper here, coming to you from Gomorrah, California.

Mary Cooper: Oh, this one's sweet. You know, for your rosary rattlers.
Leonard: Mrs Cooper, we say Catholics, not rosary rattlers.
Mary Cooper: My goodness. It's a wonder you people in California can talk at all.

Mary Cooper: I am not abandoning you, Sheldon. Abandoning you is leaving you in a basket on a church doorstep. I am going to Hollywood and thank a wax Ronald Reagan for his service to our country.

Mary Cooper: The trick to pancakes is bacon grease. I cook everything in it.
Leonard: Everything? Aren't you worried about your health?
Mary Cooper: Oh, doctors are always changing their minds. One week bacon grease is bad for you. The next week we're not getting enough of it.

Mary Cooper: Hun, you think maybe the reason why you're having trouble finding a guy to settle down with, is because you're letting them ride the roller-coaster without buying a ticket?

Mary Cooper: I thought it was our Indians that had the occasional alcohol problem.
Leonard: We don't say that either. I'll make you list.
Mary Cooper: Oh, that'd be mighty white of you.

Mary Cooper: Sheldon, your friend is hurting. What do we do when someone's hurtin'?
Sheldon: Offer them a hot beverage.
Mary Cooper: And when they're drunk as a skunk, what beverage do we offer?
Sheldon: Coffee.
Mary Cooper: And what do we do it with?
*Sheldon smiles*

Sheldon: I'm glad we're finally getting to do something together. Just the two of us.
Mary Cooper: Sure. One thing you really miss when you're on vacation is laundry.

Howard: So this spring I get to go to the International Space Station.
Mary Cooper: Oh my word. A trip to the heavens. If you ever want to live there eternally, I've got a good book you can read.