Sheldon: This place could really use a suggestion box.

Sheldon: Hawaii is a former leper colony on top of an active Volcano where the disappointing ending to Lost was filmed. Mahalo for nothing, Hawaii.

Sheldon: You've got the brilliant Sheldon Cooper in your lab and are going to ask him to do the dishes? That's like asking the Incredible Hulk to open a pickle jar.

Sheldon: Biologists are mean.

Sheldon: This is now the only lab with glassware washed by a man with two doctorates and a restraining order signed by Carl Sagan.
Amy: Soap spots. Wash them again.

Sheldon: Boy, oh, boy. This vacation is off to a wonderful start. The smell of formaldehyde, the whir of the centrifuge, the distant chatter of lab animals being dispatched for dissection. Mm, I can already feel my cares just melting away.
Amy: I'm excited to work with my boyfriend. It's going to be romantic.
Sheldon: Way to kill the mood.

Amy: Sheldon, you've never worked in a lab like this before. You have no experience in the field of biology.
Sheldon: I have plenty of experience in biology. I bought a Tamagotchi in 1998. And it's still alive. Let's do this.

Sheldon: Gentlemen, I think I've come up with a fun way to get young people interested in science. Physics Mad-Libs. Now, give me a number.
Leonard: Five.
Sheldon: Uh-huh. And an irrational constant.
Howard: E.
Sheldon: And a funny Greek letter.
Raj: Gamma.
Sheldon: I said funny.
Raj: Upsilon?
Sheldon: Good one. And an electrical charge.
Leonard: Positive.
Sheldon: Ha. Perfect. Okay. Get this. Professor Jones told the symposium he had a new method for calculating the mass of a muon. Five times the limit of E to the upsilon as in a ... (laughs uncontrollably) ... Okay. No, no. I'll start over. Professor ... (laughs again).

Howard: I haven't seen him laugh that hard since the day Leonard made that multiplication error.
Sheldon: Oh, Oh, Lord, that multiplication error! He thought he carried the one. But he didn't.
Leonard: It's not funny. That mistake got published.
Sheldon: Stop! I'm going to wet myself!

Sheldon: Oh, President Siebert, I assume you'd like to respond to one of the suggestions I put in the box by your office.
President Siebert: No, and stop installing suggestion boxes everywhere.
Sheldon: You don't like written suggestions. You don't like when I give them to you while we're urinating in the men's room. If I didn't know any better, I'd say that you're one of those stubborn people who are not open to suggestions.

Howard: How about Florida? They've got Cape Canaveral, they've got Disney, they've got my Aunt Ida and the world's largest collection of diabetic candy. Plus, if you get sweaty enough, her plastic-covered furniture is like a flume ride.
Sheldon: My family took a trip to Florida when I was a child. A seagull stole a hot dog from me on the beach. I got the message.

Leonard: Sheldon, everybody takes vacations.
Sheldon: One time they tried to make Richard Feynman take a vacation, but he chose instead to expand his mind and learn something new. He went to work in his friends biology lab. Richard Feynman was a famous American physicist, part of the Manhattan Project.
Howard: Everyone in the world of science knows who Richard Feynman was.
Sheldon: Now you do, too.

Sheldon: Oh! I have a brilliant idea. Amy's a biologist. I'll go work in her lab.
Howard: Isn't that just Feynmans idea?
Sheldon: Ten seconds ago, you never heard of him. Now you're an expert.

Sheldon: 366, 367
Amy: How's it going?
Sheldon: How's counting going? When I was in kindergarten, I recited Pi to a thousand places for the school talent show. I think I got this.
Amy: Great.
Sheldon: Aw, nuts! One

Sheldon: This is preposterous. I think you're giving me these tasks because you're afraid if you give me anything meaningful to do, I'll show you up.
Amy: Really? Is that what you think?
Sheldon: Yes, that's what I think. And I'm super smart, so it's probably true.