Amy: What if you could find a roommate who was a scientist and already familiar and comfortable with your ways.
Sheldon: That would be ideal. If a person like that existed, I would sign on, no further questions asked.
Amy: Great. Here I am!
Sheldon: Wait. Here who is where?
Amy: Me. Aren't I your perfect roommate?
Sheldon: Um...
Amy: Think about it, Sheldon. I'm not a stranger, we're both intellectually compatible, I'm willing to chauffeur you around town, and your personality quirks, which others find abhorrent and rage-inducing, I find cute as a button. What do you think?
Sheldon: Um.
Amy: Tell me one reason why this isn't a fantastic idea.
Sheldon: Um.
Amy: See? You can't. I'm gonna go see if Leonard's room is big enough for my water bed.
Sheldon: Um.

Sheldon: They can't just cancel a show like Alpha, you know. They have to help the viewers let go. Firefly did a movie to wrap things up. Buffy the Vampire Slayer continued on as a comic book. Heroes gradually lowered the quality season by season 'til we were grateful it ended.

Sheldon: Who would win in a fight, you or a shark?

Leonard: I don't think she's a whore.
Penny: Oh no, she's definitely a whore. She has no standards. ... Wait, where's Howard?
*Off screen:*
Wolowitz: Bonjour, mademoiselle. I understand you're new in town.
Sheldon: Oh, good God!

Sheldon: Well, that's a fine how-do-you-do. (To Amy) Don't just stand there. Take your breasts out.

Sheldon: I must say, I go back and fourth between this whole boyfriend-girlfriend thing, but those moments when you worship me really keep you in the running

Sheldon: I was actually trapped by Penny and forced into reveleaing confidential information about Howard's father.
Leonard: What information?
Sheldon: I can't tell you, I'm bound by closet organizer-organizee confidentiality.
Raj: Just tell us.
Sheldon: Badgering me won't work. What would work is saying Penny would tell us anyway.
Leonard: Then that.
Sheldon: Very well. Everyone's on their game today.

Penny: The letter was found in Bernadette's closet. Doesn't that count for something?
Sheldon: Are you pointing out that California is a community property state and since Howard and Bernadette are married the intellectual property contained in that letter is jointly owned by the two spouses?
Penny: Yeah, obviously.
Sheldon: Well played. Sometimes I don't give you enough credit, Penny.

Sheldon: (Typing into a search engine) How do I get 12-year-old schoolgirls excited?
Howard and Leonard: No!

Leonard: So now let's bring out theoretical physicist, Dr, Sheldon Cooper.
Sheldon: Hello, female children. Allow me to inspire you with a story about a great female scientist. Polish-born, French-educated Madame Curie. Co-discover of radioactivity. She was a hero of science until her hair fell out, her vomit and stool became filled with blood, and she was poisoned to death by her own discovery. With a little hard work, I see no reason why that can't also happen to any of you. Are we done? Can we go?

Sheldon: Some people are otters, some people are rocks.

Sheldon: Is there any reason you're keeping this dead goldfish?
Penny: Damn, I forgot to feed him. And that I had him.

Sheldon: People should take care of themselves.
Leonard: Oh, like yesterday when you made me drive you to the dry cleaners, the pharmacy and the post office?
Sheldon: I'm not saying people can't use tools. Even an otter picks up a rock when he wants a clam.

Sheldon: I believe the painful sensation felt after passing a meal of spicy chillies is proof that the rectum does possess the sense of taste.

Sheldon: Well, the equation balances, but it's certainly not elegant.
Kripke: Whatever. Did you get any last night?
Sheldon: Yes.
Kripke: Gave it to her good, huh?
Sheldon: No, I gave it to her well.