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in the episode The Novelization Correlation
Wil Wheaton: [on TV] It's time for Professor Proton's science joke of the day. Why can you not trust atoms?
Wil Wheaton: [on TV] Because they make up everything.
Sheldon: Oh, that's funny! Yeah, because they do. They make up everything.
This helps us figure out whether you are a human or a cyborg.