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Quote from Sheldon in the episode The VCR Illumination

Amy: Oh, so now you're reevaluating every opinion you've ever had?
Sheldon: Yes. I am following the example of 17th century philosopher René Descartes.
He subjected all his beliefs to radical doubt so that he could build a bedrock belief and build his cognitive life back up on firm principles. [eating asparagus] Ugh! Still yucky, still yucky.

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