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in the episode The Change Constant
Sheldon: What do you want, Howard?
Howard: We were just calling to see if you'd heard yet.
Sheldon: We haven't.
Amy: But thank you for getting up so early to call. That was very thoughtful.
Bernadette: Oh, please. We have two little kids. We've been up for an hour.
This helps us figure out whether you are a human or a cyborg.