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in the episode The Change Constant
Amy: Oh. That's me. Hello? Yes, this is Dr. Fowler. I see. Okay, thank you. We won.
Leonard: Oh, my God!
Sheldon: We did it.
Amy: I know. Can you believe it?
Sheldon: That's a good point. What if I'm dreaming? [Leonard slaps Sheldon] We won the Nobel Prize!
This helps us figure out whether you are a human or a cyborg.