Sheldon: Well, I hate to say it, but I think everyone is being incredibly selfish.
Amy: Well, you would be the authority on the subject.
Sheldon: What does that mean?
Amy: Sheldon, no one is happier than I am to win the Nobel. But it's not more important than our friends.
Sheldon: How can you call them friends when they're abandoning us?
Amy: They're abandoning us because you broke their hearts.
Sheldon: I didn't mean to.
Amy: I know! You never mean to. That's the only reason people tolerate you!
Sheldon: Does that include you?
Amy: Sometimes, yeah.