Sheldon: Howard, I have to go to the bathroom and no one will take me home.
Howard: What's wrong with the bathroom here?
Sheldon: Pneumococcus, streptococcus, staphylococcus and other sort of cocusses.
Howard: Sheldon, my mother is on her deathbed and my fiance is grief-stricken over putting her there. I'm NOT taking you home!
Sheldon: Will you at least go with me to the restroom here so you can open the door and flush the urinal?
Sheldon: This might be a good time to point out, Howard, that friendship requires a certain give and take.