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Quote from Leslie Winkle in the episode The Bat Jar Conjecture
Howard: We'll just have to face Sheldon mano y mano y mano a mano.
Leslie: Wait, you're going up against Sheldon Cooper?
Leslie: That arrogant, misogynistic, East Texas doorknob that told me I should abandon my work with high-energy particles for laundry and child bearing?
Leonard: She's in!
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