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in the episode The Vartabedian Conundrum
Stephanie: I don't see anything at all, Sheldon. Sheldon: Well, you're the doctor, but I am constantly hearing this annoying sound.
Leonard: Me too.
Sheldon: Is it a high frequency whistle? Leonard: No, it's more of a relentless, narcissistic drone.
This helps us figure out whether you are a human or a cyborg.