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in the episode The Friendship Turbulence
Sheldon: Leonard, could you wrap it up? We're waiting on you.
Penny: I'm sorry, is the fact my life's falling apart interfering with your board game?
Sheldon: It is.
*Sheldon goes back into the apartment*
Sheldon: You were wrong, Friend Howard. She completely understood.
This helps us figure out whether you are a human or a cyborg.