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in the episode The Friendship Turbulence
Sheldon: I'm sorry for every mean thing I ever did or said to you.
Howard: I'm sorry too. It's all my fault.
Sheldon: If you weren't my friend there'd be a hole in my life.
Howard: Thank you, Sheldon.
Sheldon: Kind of like when Firefly was cancelled, but not as big.
This helps us figure out whether you are a human or a cyborg.