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in the episode The Locomotion Interruption
Leonard: Sheldon, hang tight. Hey, do you want me to bring you anything?
Sheldon: Yes, please. A pair of pants, and my toothbrush, and my mail, and a really good come back for chicken legs. Because "I know you are, but what am I?" was met with stony silence.
This helps us figure out whether you are a human or a cyborg.