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in the episode The Misinterpretation Agitation
Howard: How'd you get that?
Dr. Lorvis: Easy. Gene Rodenberry needed a vasectomy.
Sheldon: You've snipped Gene Rodenberry's vas deferens?
Dr. Lorvis: Yes.
Howard: Wow, you really went where no man has gone before.
This helps us figure out whether you are a human or a cyborg.