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in the episode The Closet Reconfiguration
Sheldon: What can I do for you ladies?
Amy: You have something we want.
Sheldon: Oh, dear. My mother warned me this is what happens to pretty boys in the big city.
Penny: No, we just want information.
Sheldon: Oh. I've got that spades. Ravage me.
This helps us figure out whether you are a human or a cyborg.