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Quote from Sheldon in the episode The Earworm Reverberation

Sheldon: Sheldon Cooper's descent into madness day two. It's 2:25 a.m. and I feel the urge to urinate. My normal urination time is 7:10 a.m., but here I am, in the middle of the night, struggling to keep my mind sharp and my pajamas dry. It's only a matter of time before my tenuous grasp on reality fades. I suppose I should pee while I still know what a toilet is.

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