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Quote from Leonard in the episode The Earworm Reverberation

Sheldon: Well, I shouldn't be surprised. There's a rich history of brilliant minds descending into madness.
Penny: Come on, Sheldon. There are plenty of smart people who don't have mental problems.
Leonard: Yup, she's right. For every Newton who had a psychological issue, there's an Edison who was just a jerk. That could totally be you.

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