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Quote from Sheldon in the episode The Sales Call Sublimation
Sheldon: Enjoy the neurobiology conference.
Amy: I will. I wish you were here.
Sheldon: At a neurobiology conference? What a mean thing to say.
Amy: Okay, I'm glad you're not here?
Sheldon: Aww, you always know just what to say after I tell you what to say.
This helps us figure out whether you are a human or a cyborg.