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in the episode The Precious Fragmentation
Howard: I'll bet your Meemaw didn't just have sex to have your mother, I bet she had sex because she liked it.
Sheldon: Stop it!
Raj: Yeah, Meemaw did the nasty.
Sheldon: I said stop it!
Howard: We're getting to him.
This helps us figure out whether you are a human or a cyborg.