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in the episode The Meemaw Materialization
Sheldon: Here's a fun Postal fact. Yeah, the inner side of our mailbox is under federal jurisdiction. So, if you broke my right thumb, that's Pasadena city police. But if you broke my left thumb, that's the FBI.
Leonard: If I'm going to jail, I'm killing him, not breaking his thumb.
This helps us figure out whether you are a human or a cyborg.