Sheldon: Ooh, hey, oh, ask her to do the tissue thing. Do it, ask her.
Amy: Can I have a tissue?
Meemaw: Of course. (Meemaw pulls a tissue out of her sleeve)
Sheldon: Isn't that the best?! She's like Grandma Spider-Man.
Meemaw: He's been saying that since he was little. I still don't know what it means.