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in the episode The Positive Negative Reaction
Sheldon: Where's the bathroom?
Raj: Uh, it's in the corner.
Sheldon: Excuse me.
(To strangers at another table)
Hey, how you doin'?
Raj: I hope the bathroom is clearly marked.
Leonard: Doesn't matter. He's headed for the kitchen anyway.
This helps us figure out whether you are a human or a cyborg.