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in the episode The Celebration Experimentation
Howard: Sheldon, I don't think everyone-
Sheldon: Wolowitz, perfect. Everyone listen to Wolowitz.
Howard: Okay, then, uh, Sheldon, we've known each other a long time. And it is a pleasure to work with you and call you my friend.
Sheldon: Little generic. Keep thinking. We'll circle back.
This helps us figure out whether you are a human or a cyborg.