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in the episode The Fermentation Bifurcation
Bernadette: It's okay, you should go.
Howard: You sure?
Bernadette: Of course.
Penny: Yeah, give her a break from, well, come on.
Sheldon: Well, Bernadette, looks like Saturday night, it's you and me.
Bernadette: Me? How? Why?
This helps us figure out whether you are a human or a cyborg.