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in the episode The Stag Convergence
Raj: May I have your attention, please? We are here tonight to celebrate the upcoming nuptials of my best friend Howard Wolowitz.
Everybody: Hear! Hear!
Sheldon: And apparently Wil Wheaton's best friend.
Wil Wheaton: Sheldon...
Sheldon: Talk to the hand.
This helps us figure out whether you are a human or a cyborg.