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in the episode The Rothman Disintegration
Raj: How about you decide this with Rock-Paper-Scissors-Lizard-Spock?
Barry Kripke: What the frig is that?
Sheldon: Rock-Paper-Scissors-Lizard-Spock was created by Internet pioneer Sam Kass as an improvement on the classic game Rock-Paper-Scissors. All hail Sam Kass.
This helps us figure out whether you are a human or a cyborg.