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in the episode The Cognition Regeneration
Howard: Now, this is rare. I don't know which one of you I want to stop talking first.
Sheldon: The theory is that if you really tax your brain, the neurofibers will become thicker and the glial cells more lustrous.
Raj: Like JLo's hair.
Howard: Boy, it is neck and neck right now.
This helps us figure out whether you are a human or a cyborg.