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in the episode The Cognition Regeneration
Howard: All right, this is everything. What do you want to learn?
Sheldon: It really doesn't matter, as long as it's challenging.
Howard: Okay, well, how about, oh, I teach you some close-up magic.
Sheldon: Howard, I'm trying to make myself uncomfortable, not everyone else.
This helps us figure out whether you are a human or a cyborg.