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in the episode The Vartabedian Conundrum
Leonard: She's heard about you because we're, you know, involved. And you haven't heard about her because ... I never slept with her, I swear!
Sheldon: In Leonard's defense, it wasn't for lack of trying.
Leonard: Thank you, Sheldon.
Sheldon: You're welcome, Leonard.
This helps us figure out whether you are a human or a cyborg.