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Quote from Penny in the episode The Jerusalem Duality

Leonard: Well, what are you going to do, Sheldon, give up?
Sheldon: Yes. That's what a rational person does when his entire life's work is invalidated by a post-pubescent Asian wunderkind. He ceases his fruitless efforts, he donates his body to scientific research, and he waits to die.
Penny: You know, I'm confused again. Is he waiting, or do we get to shoot him between the eyes?

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