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in the episode The Explosion Implosion
Leonard: It's okay. We're all here to help.
Sheldon: Yes. And this baby will have plenty of manly role models. Now, I'm certain that whatever Bernadette can't teach him, Penny can.
Leonard: Uh, she can pee into a bottle.
Penny: Mm-hmm. Anything with a neck wider than a nickel.
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