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in the episode The Explosion Implosion
Beverly Hofstadter: Hi, Pen- Oh, hello, Leonard.
Leonard: Hello, Mother. How are you?
Beverly Hofstadter: Fine. And you?
Leonard: I'm great.
Beverly Hofstadter: Well, it's been lovely catching up.
Leonard: Wait. Hang on. We need to talk.
Beverly Hofstadter: Oh, brother.
This helps us figure out whether you are a human or a cyborg.