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in the episode The Desperation Emanation
Sheldon: Amy Farrah Fowler has asked me to meet her mother.
Leonard: Yeah, so?
Sheldon: What does that mean?
Leonard: Well, you know how you're always saying Amy is a girl who is your friend but not your girlfriend?
Sheldon: Uh huh.
Leonard: Well, you can't say that any more.
This helps us figure out whether you are a human or a cyborg.