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in the episode The Holographic Excitation
Howard: So, here we are, just a couple of young newlyweds. What to do? What to do to you? Astronaut Wolowitz, reporting for booty. Preparing thrusters. We have liftoff. Are we clear to jettison that nightgown?
Bernadette: Okay, we need to talk.
This helps us figure out whether you are a human or a cyborg.