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in the episode The Confidence Erosion
Dr. Koothrappali: I, too, was in a relationship with someone who made me feel bad about myself.
Raj: If you're talking about Mom, I don't want to hear it.
Dr. Koothrappali: I'm just saying, if you replace Howard with a nice 22-year-old grad student, your self-confidence will soar.
This helps us figure out whether you are a human or a cyborg.