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Quote from Sheldon in the episode The Einstein Approximation

Penny: Whatcha doin'?
Sheldon: I'm attempting to view my work as a fleeting peripheral image so as to engage the superior coliculus of my brain.
Penny: Interesting. I usually just have coffee. Have you been up all night?
Sheldon: Is it morning?
Penny: Yes.
Sheldon: Then I've been up all night.

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